Steve Paul, M.D.

Venture Partner

Steve Paul

Steve has over 40 years of experience as a physician-scientist specializing in neuroscience and molecular neuropharmacology as well as CNS drug discovery and development. He first joined Third Rock in 2010 and returned in 2018 as a venture partner. Steve is the scientific co-founder of Sage Therapeutics and served as its interim start-up head of R&D. He is also the co-founder of Voyager Therapeutics, a CNS gene therapy company, and served as its president and CEO. Steve also served as the CEO and chairman of Karuna Pharmaceuticals, a company developing novel treatments for schizophrenia and dementia-related psychosis in Alzheimer’s disease. Steve is the former director of the Appel Alzheimer Disease Research Institute at Weill Cornell Medical College and is currently a professor of psychiatry and neurology at Washington University of St. Louis School of Medicine. Prior to his appointments at Weill Cornell and Washington University, Steve spent 17 years at Eli Lilly and Company, during which time he held several key R&D leadership roles including Executive Vice President for Science and Technology and President of the Lilly Research Laboratories. Prior to Lilly, Steve spent 18 years at NIH and as the scientific director of the National Institute of Mental Health.

Steve has been the recipient of many awards and honors and has served on numerous committees and advisory boards. He has authored or co-authored more than 550 papers and book chapters. Steve is an elected fellow of the American Association for the Advancement of Science and a member of the National Academy of Medicine of the National Academy of Sciences. He is also an elected fellow emeritus of the American College of Neuropsychopharmacology (ACNP) and served as ACNP President (1999). Steve is also currently on the board of directors or is a trustee of several organizations, including serving as Chairman of the Board of the Foundation for the NIH (FNIH) Sage Therapeutics, Karuna Therapeutics and Rapport Therapeutics. Steve has also served as a member of the National Institute of General Medical Sciences (NIGMS) and the National Institute of Mental Health Advisory Councils and was appointed by the secretary of the Department of Health and Human Services (HHS) as a member of the Advisory Committee to the Director of the NIH from 2001-2006 as well as to the science board of the FDA (2012-2014).

Year Joined
  • 2010
  • Tulane University, B.A., Biology and Psychology
  • M.S., Tulane University School of Medicine
  • M.D., Tulane University School of Medicine
  • East Coast
Board Positions