Jeremy Caldwell joined Third Rock in 2014 as an Entrepreneur-in-Residence, bringing more than 15 years experience leading science-driven organizations in biotech research institutes and large pharma.
Prior to joining Third Rock Ventures, Jeremy served as Vice President, Head of RNA Therapeutics, Screening and Protein Sciences for Merck Research Laboratories (MRL). In this role, he oversaw the discovery and development of RNA-based therapeutics including siRNA discovery, RNA delivery and pipeline enabling technologies as well as early lead generation in screening and protein sciences. Before that, he led the integration of legacy Merck and legacy Schering Plough discovery and preclinical functions as the founding head of Strategic Operations. Prior to joining Merck in 2008, Jeremy was Executive Director of molecular and cellular biology, lead discovery and genomics at the Genomics Institute of the Novartis Research Foundation (GNF). Additionally, he was Chairman and Head of GNF Technology and Research. He has worked as an independent consultant to several biotechnology companies in the areas of proteomics, cell-based drug discovery and preclinical toxicology technologies. Jeremy co-founded the biopharmaceutical company Kalypsys, Inc.
Jeremy has been lead inventor on more than 17 issued/pending patent applications in molecular biology, drug/gene discovery and medical devices. He has authored or co-authored more than 50 journal articles and three book chapters, and he is a member of the Society for Bio-molecular Screening, American Society for Microbiology and the American Association of Cancer Research. Jeremy received a Ph.D. in molecular pharmacology from Stanford University. He holds an undergraduate degree in molecular and cellular biology with an emphasis in neurobiology from the University of California at Berkeley.
Year Joined Third Rock
Jeremy Caldwell, PhD
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James Geraghty joined Third Rock in 2013. Having helped Genzyme launch rare disease therapies around the world, Jim will assist the firm in creating companies focused on rare genetic diseases and support existing portfolio companies in related spaces.
Prior to joining Third Rock, Jim served as Senior Vice President, North America strategy and business development, at Sanofi. Before Sanofi, Jim spent 20 years at Genzyme Corporation, most recently as Senior Vice President and an Officer. While at Genzyme, his roles include President of Genzyme Europe and General Manager of Genzyme's cardiovascular business. He also led strategic transactions that brought important new products into Genzyme. He served as a director of GTC Biotherapeutics (formerly Genzyme Transgenics Corporation), where he was previously Chairman, President and CEO. Jim also oversaw Genzyme's Humanitarian Assistance for Neglected Diseases program, under which Genzyme helped develop innovative therapeutic programs on a non-commercial basis. He served as co-chair of the executive committee for BIO 2007, and continues to serve on the board of Bio Ventures for Global Health (BVGH). A graduate of the Yale Law School, he has published articles in the Yale Law Journal, Health Affairs and other publications. He holds an MS from the University of Pennsylvania and a BA from Georgetown University.
Bob Kamen joined Third Rock Ventures in 2010 as an Entrepreneur-in-Residence, bringing with him more than 30 years of experience in the pharmaceutical and biotechnology industries. Most recently, he served as President of Abbott Bioresearch Center, where he oversaw the discovery and production of Humira®, the first fully human antibody to achieve marketing approval in the U.S. and Europe, and was a member of the Abbott Pharmaceuticals Executive Management Committee. Bob also served as the President of BASF Bioresearch Corp., until it was acquired by Abbott Laboratories in 2001. Earlier in his career, Bob led discovery at Genetics Institute, Inc.
In 2005, he co-founded BioAssets Development Corporation, a biotherapeutics company focusing on spinal diseases. Cephalon exercised its option to acquire BioAssets in 2010. Bob serves as a director of Harbour Antibodies BV, Lycera Corp. and Opsonic Therapeutics and advises other biopharmaceutical companies. Bob has an undergraduate degree in biophysics from Amherst College and a PhD in biochemistry and molecular biology from Harvard University.
Interim Chief Technology Officer of Jounce Therapeutics
Uday N. Kumar joined Third Rock Ventures in 2012 as an Entrepreneur-in-Residence, where he focuses on leading the development of new medical devices and technologies.
Uday, a cardiologist and cardiac electrophysiologist, is the Founder of iRhythm Technologies, Inc., a medical device company focused on developing cost-effective new devices and systems for cardiac rhythm monitoring. He served as a board member and Chief Medical Officer of iRhythm from founding through broad commercialization of its Zio® Patch cardiac monitoring device. Uday is also Co-founder and board member of Sympara Medical, Inc., a company developing a novel therapy for hypertension. He currently serves on the Consulting Faculty of Bioengineering at Stanford University and is the Fellowship Director for Stanford's Biodesign Global Programs (India and Singapore), programs that teach processes for medical innovation to solve unmet medical needs globally. Additionally, he is on the Steering Committee for Value-driven Engineering and U.S. Global Competitiveness, an initiative focused on developing policies and recommendations to promote and retain U.S. leadership in medical device development and innovation.
Uday was a biodesign fellow at Stanford, a cardiac electrophysiology and cardiology fellow at the University of California, San Francisco, and internal medicine resident at Columbia-Presbyterian Hospital of Columbia University. Prior to his training, Uday was Vice President and Chief Medical Officer of Biomedical Modeling Inc., a start-up company that created rapid prototyping models from imaging data for use in numerous medical applications. Uday received his M.D. and B.A. in biochemistry and molecular biology from Harvard University.
David Pompliano joined Third Rock in 2013 as an Entrepreneur-in-Residence. He focuses on creating scientifically precocious, game-changing new enterprises that apply the science of human-microbe interactions to discover and deliver new medicines and diagnostic tools.
He has over 20 years of experience in the biopharmaceutical industry, most recently as CEO of BioLeap, a discovery stage platform technology company. Before that, he was a senior pharmaceutical executive at GlaxoSmithKline and Merck, where he led drug discovery teams that produced pre-clinical credentials for >30 development candidates and four registered anti-infective (Altabax) and oncology (Tykerb, Votrient, Promacta) drugs.
David earned the BS and PhD degrees in Chemistry from the University of Virginia and from Stanford University, respectively, and was an NIH Postdoctoral Fellow in Jeremy Knowles’ laboratory at Harvard University. He also is Principal and Owner at Sanderling Consulting LLC, where he assists investors, companies and philanthropies in setting drug discovery strategy, in executing the operations of preclinical discovery and development, and in evaluating pharmaceutical assets. David serves on the Scientific Advisory Boards of several biotechnology companies.
Year Joined Third Rock
David L. Pompliano, PhD